Endocrine Abstracts

Background: One of the major complications developed by patients with end stage renal disease (ESRD) is secondary hyperparathyroidism (SHPT), due to hypocalcaemia, hyperphosphatemia and 1,25(OH)2D deficiency with parathyroid hyperplasia and high PTH levels as earliest changes, which may require parathyroidectomy (PTX).Study design and objectives: This study aimed to evaluate the indications, the particularities and outcomes post-PTX of patient...

Prolactinoma registry is part of the Romanian national Registry of Endocrine Tumors system (www.renate.ro), which allows the collection and provides epidemiological data concerning the prevalence of age and sex distribution, therapy and its basic results. The centers involved are the medical universities and expertise centers in Romania, centers in which exist enough experience and resources to diagnose, treat and monitor the evolution of the...

Prolactinoma (PRM) treatment is based upon dopamine agonists, cabergoline (CAB) being one of the most used in the last decade. Sensitivity to CAB varies in terms of tumour volume and PRL secretion, up to 8–15% of PRM being defined as resistant. Since it is known that increasing the dosage improves the response rate, we aimed to measure plasma CAB levels in PRM patients under this treatment in a prospective interventional study.Patients and methods: ...

Cabergoline (CAB) is a selective dopamine D2-receptor agonist with long-lasting action, highly effective in treating micro- and macroprolactinoma. However, the clinical response to cabergoline can be seen only after several months of treatment, allowing the tumor shrinkage and decrease of prolactin. Despite most prolactinomas are responsive to CAB, there are up to 8% of cases in which tumor responsivity is limited. In order to asses the sensitivity to Cab, we aimed to develop ...

Primary therapy in prolactinomas, the most frequent pituitary adenomas, consists in ergot derivatives dopamine agonists (bromocriptine or cabergoline) which lowers prolactin levels and shrink the tumour. Bromocriptine was the first drug used, but the therapeutic levels are attained after several days/weeks, therefore an acute suppression test is not possible. However, the biological response is variable and 10% of prolactinomas are resistant to medical therapy. In order to eva...

Background: Head trauma of sufficient severity, particularly causing fracture to the skull base, can cause deficient secretion of anterior pituitary hormones and vasopressin. Severe hypopituitarism and diabetes insipidus (DI) are common post-traumatic events but they can recover 3 and 12 months afterwards.Objective: To report a case of a woman with post-traumatic hypopituitarism and DI after car accident.Case report: A 31 year old ...

IntroductionThyrotropinoma is a rare pituitary tumor ( <2% of pituitary adenomas) arising from PIT1-lineage cells, which expresses and secrete TSH. In most cases, the etiology is unknown but rare cases have been described to arise in context of MEN 1 syndrome. Diagnosis is often delayed by confusion with primary hyperthyroidism, which determine the tumor to be already large and invasive at the time of diagnosis. GH and prolactin cosecretion is an increas...

BackgroundCushing syndrome (CS) is caused by prolonged exposure to elevated cortisol levels and it’s classified as either ACTH-dependent or ACTH independent CS. The most common form of endogenous ACTH CS is Cushing disease (CD); ACTH-independent CS is caused by various adrenal abnormalities. First-line therapy in CS is the resection of the underlying tumor in all cases. After surgical cure of CS, most patients develop transient secondary adrenal ins...

Clinical fetal thyrotoxicosis is a rare disease occurring in 1-5% of pregnancies with Graves disease. Although transplacental passage of maternal TSH receptor stimulating autoantibodies (TRab) to the fetus does occur early in gestation, the fetal concentration is low until the end of second trimester, but reaches maternal levels in the last period of pregnancy. The mortality of fetal thyrotoxicosis is 12–20% mainly due to heart failure. We present a case of fetal and neo...

Introduction: Pituitary adenomas are the most common pituitary tumours, but in 18% of cases we can find other rare tumours like: Rathke’s cleft cyst, craniopharingyomas, chordomas, meningiomas, infiltrative or infectious disease. Meningeal melanocytoma is a benign neoplasm of central nervous system, commonly located in the base of the brain, cerebellopontine angle and the pineal body, difficult to differentiate from a nonfunctional p...